7JUY Chain B
Kinase suppressor of Ras 1 (KSR1)
Inactive — 0.0%DFG-inαC-outATPlike · ANP
Resolution
3.096 Å
R-value
0.248
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLP
UniProt reference sequence
VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEK
Aligned reference sequence
VELG----------------EPIGQGR----------------WGRVHRGRW-----------------------------------------HGEVAIRLLE--MDGHNQDH--------------------------LKLFKKEVMNYRQT--------------------------RHENVVLFMGACMNPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAIITSFCKG--------------RTLHSFVRD--PKT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDINKTRQIAQEIIKGMGYLHAK---------------------------------------------GIVHKDL-----KSKNVFYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKVVITDFGLFGISGVVREG--RRENQL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSHDWLCYLAPEIVRE--MTPGKDEDQ---------------------LPFS-KAADVYAFGTVWYELQAR-----------------DWPLKN--------------------------------------------------QAAEASIWQIGSG--EGMKRVLTSVSLG--------------------------------------------------------------------------------------------------KEVSEILSACWAFDLQERPS--------------FSLLMDMLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VELG----------------EPIGQGR----------------WGRVHRGRW-----------------------------------------HGEVAIRLLE--MDGHNQDH--------------------------LKLFKKEVMNYRQT--------------------------RHENVVLFMGACMNPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAIITSFCKG--------------RTLHSFVRD--PKT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDINKTRQIAQEIIKGMGYLHAK---------------------------------------------GIVHKDL-----KSKNVFYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKVVITDFGLFGISGVV-------ENQL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSHDWLCYLAPEIVRE--MTPGKDEDQ---------------------LPFS-KAADVYAFGTVWYELQAR-----------------DWPLKN--------------------------------------------------QAAEASIWQIGSG--EGMKRVLTSVSLG--------------------------------------------------------------------------------------------------KEVSEILSACWAFDLQERPS--------------FSLLMDMLEK
Activation segment
DFGLFGISGVV-------ENQL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSHDWLCYLAPE
Binding pocket
EPIGQGRWGRVHRVAIRLLLFKKEVMNYRQTRENVVLFMGAAIITSFCKGRTLHSFVRDYLHAKGIVHKDLKSKNVFYITDFGLF
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7JUY, Chain B