7JUU Chain B
Kinase suppressor of Ras 2 (KSR2)
Inactive — 0.0%DFG-inαC-outATPlike · ANP
Resolution
3.19 Å
R-value
0.242
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
TSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLP
UniProt reference sequence
LEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEK
Aligned reference sequence
LEIG----------------ELIGKGR----------------FGQVYHGRW-----------------------------------------HGEVAIRLID--IERDNEDQ--------------------------LKAFKREVMAYRQT--------------------------RHENVVLFMGACMSPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAIITSLCKG--------------RTLYSVVRD--AKI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLDVNKTRQIAQEIVKGMGYLHAK---------------------------------------------GILHKDL-----KSKNVFYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKVVITDFGLFSISGVLQAG--RREDKL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIQNGWLCHLAPEIIRQ--LSPDTEEDK---------------------LPFS-KHSDVFALGTIWYELHAR-----------------EWPFKT--------------------------------------------------QPAEAIIWQMGTG--MKPNLSQIGMG----------------------------------------------------------------------------------------------------KEISDILLFCWAFEQEERPT--------------FTKLMDMLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LEIG----------------ELIGKGR----------------FGQVYHGRW------------------------------------------GEVAIRLID--IERDNEDQ--------------------------LKAFKREVMAYRQT--------------------------RHENVVLFMGACMSPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLAIITSLCKG--------------RTLYSVVRD--AKI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLDVNKTRQIAQEIVKGMGYLHAK---------------------------------------------GILHKDL-----KSKNVFYD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGKVVITDFGLFSISGVLQ-----REDKL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIQNGWLCHLAPEIIRQ--LSPDTEEDK---------------------LPFS-KHSDVFALGTIWYELHAR-----------------EWPFKT--------------------------------------------------QPAEAIIWQMGTG--MKPNLSQIGMG----------------------------------------------------------------------------------------------------KEISDILLFCWAFEQEERPT--------------FTKLMDMLEK
Activation segment
DFGLFSISGVLQ-----REDKL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIQNGWLCHLAPE
Binding pocket
ELIGKGRFGQVYHVAIRLIAFKREVMAYRQTRENVVLFMGAAIITSLCKGRTLYSVVRDYLHAKGILHKDLKSKNVFYITDFGLF
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7JUU, Chain B