7JU6 Chain A
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Active — 99.6%DFG-inαC-inType1 · Q6G
Resolution
2.06 Å
R-value
0.199
Predicted activity confidence99.6%
Structure info
Alternate conformationA
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR
UniProt reference sequence
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK
Aligned reference sequence
LVLG----------------KTLGEGE----------------FGKVVKATA--FHLKGRA-------------------------------GYTTVAVKMLK--ENASPSE---------------------------LRDLLSEFNVLKQV--------------------------NHPHVIKLYGACSQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLIVEYAKY--------------GSLRGFLRE--SRKVGPGYLGSGGSRNSSSLDHPDER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALTMGDLISFAWQISQGMQYLAEM---------------------------------------------KLVHRDL-----AARNILVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKMKISDFGLSRDVYEEDSY--VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIESLFD--------------------------------HIYT-TQSDVWSFGVLLWEIVTL--G--------------GNPYPG--------------------------------------------------IPPERLFNLLKTG--HRMERPDNCS-----------------------------------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV--------------FADISKDLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KTLGEGE----------------FGKVVKATA--FHLKGRA-------------------------------GYTTVAVKMLK--ENASPSE---------------------------LRDLLSEFNVLKQV--------------------------NHPHVIKLYGACSQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLIVEYAKY--------------GSLRGFLRE--SRKVGPGYLG------------PDER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALTMGDLISFAWQISQGMQYLAEM---------------------------------------------KLVHRDL-----AARNILVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKMKISDFGLSRDVYEEDSY--VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIESLFD--------------------------------HIYT-TQSDVWSFGVLLWEIVTL--G--------------GNPYPG--------------------------------------------------IPPERLFNLLKTG--HRMERPDNCS-----------------------------------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV--------------FADISKDLEK
Activation segment
DFGLSRDVYEEDSY--VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIE
Binding pocket
KTLGEGEFGKVVKVAVKMLDLLSEFNVLKQVNPHVIKLYGALLIVEYAKYGSLRGFLREYLAEMKLVHRDLAARNILVISDFGLS
Ligand info
Orthosteric ligand
Q6G
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7JU6, Chain A