7JU5 Chain A
Proto-oncogene tyrosine-protein kinase receptor Ret (RET)
Inactive — 29.0%DFG-inαC-inType1 · Q4J
Resolution
1.9 Å
R-value
0.191
Predicted activity confidence29.0%
Structure info
Alternate conformationB
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GPLSLSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR
UniProt reference sequence
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK
Aligned reference sequence
LVLG----------------KTLGEGE----------------FGKVVKATA--FHLKGRA-------------------------------GYTTVAVKMLK--ENASPSE---------------------------LRDLLSEFNVLKQV--------------------------NHPHVIKLYGACSQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLIVEYAKY--------------GSLRGFLRE--SRKVGPGYLGSGGSRNSSSLDHPDER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALTMGDLISFAWQISQGMQYLAEM---------------------------------------------KLVHRDL-----AARNILVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKMKISDFGLSRDVYEEDSY--VKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIESLFD--------------------------------HIYT-TQSDVWSFGVLLWEIVTL--G--------------GNPYPG--------------------------------------------------IPPERLFNLLKTG--HRMERPDNCS-----------------------------------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV--------------FADISKDLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KTLGEGE----------------FGKVVKATA--FHLKGRA-------------------------------GYTTVAVKMLK--ENASPSE---------------------------LRDLLSEFNVLKQV--------------------------NHPHVIKLYGACSQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLLIVEYAKY--------------GSLRGFLRE--SRKVG-------------------ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALTMGDLISFAWQISQGMQYLAEM---------------------------------------------KLVHRDL-----AARNILVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKMKISDFGLSRDVY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIESLFD--------------------------------HIYT-TQSDVWSFGVLLWEIVTL--G--------------GNPYPG--------------------------------------------------IPPERLFNLLKTG--HRMERPDNCS-----------------------------------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV--------------FADISKDLEK
Activation segment
DFGLSRDVY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQGRIPVKWMAIE
Binding pocket
KTLGEGEFGKVVKVAVKMLDLLSEFNVLKQVNPHVIKLYGALLIVEYAKYGSLRGFLREYLAEMKLVHRDLAARNILVISDFGLS
Ligand info
Orthosteric ligand
Q4J
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7JU5, Chain A