7EJV Chain B
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)
Active — 98.7%DFG-inαC-inType1 · YK2
Resolution
2.5 Å
R-value
0.202
Predicted activity confidence98.7%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP
UniProt reference sequence
YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
Aligned reference sequence
YEVL----------------KVIGKGS----------------FGQVVKAYD--HK------------------------------------VHQHVALKMVR--NEKRF-----------------------------HRQAAEEIRILEHL--RKQDKD------------------NTMNVIHMLENFTFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICMTFELLS---------------MNLYELIKK--NKFQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSLPLVRKFAHSILQCLDALHKN---------------------------------------------RIIHCDL-----KPENILLKQ--QG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSGIKVIDFGSSCYEHQRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTYIQSRFYRAPEVILG--------------------------------ARYG-MPIDMWSLGCILAELLTG-----------------YPLLPG--------------------------------------------------EDEGDQLACMIEL--LGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD-------------------------------------------PLFLDFLKQCLEWDPAVRMT--------------PGQALRHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEVL----------------KVIGKGS----------------FGQVVKAYD--HK------------------------------------VHQHVALKMVR--NEKRF-----------------------------HRQAAEEIRILEHL--RKQDKD------------------NTMNVIHMLENFTFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICMTFELLS---------------MNLYELIKK--NKFQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSLPLVRKFAHSILQCLDALHKN---------------------------------------------RIIHCDL-----KPENILLKQ--QG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSGIKVIDFGSSCYEHQRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YT-IQSRFYRAPEVILG--------------------------------ARYG-MPIDMWSLGCILAELLTG-----------------YPLLPG--------------------------------------------------EDEGDQLACMIEL--LGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD-------------------------------------------PLFLDFLKQCLEWDPAVRMT--------------PGQALRHPWL
Activation segment
DFGSSCYEHQRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YT-IQSRFYRAPE
Binding pocket
KVIGKGSFGQVVKVALKMVQAAEEIRILEHLRMNVIHMLENCMTFELLS_MNLYELIKKALHKNRIIHCDLKPENILLVIDFGSS
Ligand info
Orthosteric ligand
YK2
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7EJV, Chain B