7EED Chain A
Ephrin type-A receptor 7 (EPHA7)
Inactive — 0.4%DFG-inαC-in
Resolution
3.05 Å
R-value
0.201
Predicted activity confidence0.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLAHMGYVHRDLAARNILVNSNLVCKVSDFGLSPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSAHH
UniProt reference sequence
IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDK
Aligned reference sequence
IKIE----------------RVIGAGE----------------FGEVCSGRL--KLPGK---------------------------------RDVAVAIKTLK--VGYTEKQ---------------------------RRDFLCEASIMGQF--------------------------DHPNVVHLEGVVTRGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVIEFMEN--------------GALDAFLRK--HDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMRYLADM---------------------------------------------GYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVIEDDPEA--VYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGGKIPVRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVIKAIEEG--YRLPAPMDCP-----------------------------------------------------------------------------------------------------AGLHQLMLDCWQKERAERPK--------------FEQIVGILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKIE----------------RVIGAGE----------------FGEVCSGRL--KLPGK---------------------------------RDVAVAIKTLK--VGYTEKQ---------------------------RRDFLCEASIMGQF--------------------------DHPNVVHLEGVVTRGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVIEFMEN--------------GALDAFLRK--HDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMRYLAHM---------------------------------------------GYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVIKAIEEG--YRLPAPMDCP-----------------------------------------------------------------------------------------------------AGLHQLMLDCWQKERAERPK--------------FEQIVGILDK
Activation segment
DFGLS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVRWTAPE
Binding pocket
RVIGAGEFGEVCSVAIKTLDFLCEASIMGQFDPNVVHLEGVMIVIEFMENGALDAFLRKYLAHMGYVHRDLAARNILVVSDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7EED, Chain A