7CQE Chain C
Tyrosine-protein kinase Mer (MERTK)
Inactive — 0.0%DFG-inαC-outType1 · YDJ
Resolution
2.69 Å
R-value
0.203
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues9
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
EDVVIDRNLLILGKILGSVMEGNLKQEDGTSLKVAVKTFLSEAACMKDFSHPNVIRLLGVCIKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL
UniProt reference sequence
LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK
Aligned reference sequence
LILG----------------KILGEGE----------------FGSVMEGNL--KQEDG---------------------------------TSLKVAVKTMK--LDNSSQRE--------------------------IEEFLSEAACMKDF--------------------------SHPNVIRLLGVCIEMS--SQGIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGLSKKIYSGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIAKMPVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LILG----------------KIL---------------------GSVMEGNL--KQEDG---------------------------------TSLKVAVKT-----------------------------------------FLSEAACMKDF--------------------------SHPNVIRLLGVCI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIE
Binding pocket
KIL_____GSVMEVAVKT__FLSEAACMKDFSPNVIRLLGVMVILPFMKYGDLHTYLLYYLSNRNFLHRDLAARNCMLVADFG__
Ligand info
Orthosteric ligand
YDJ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7CQE, Chain C