7CML Chain A
Mitogen-activated protein kinase 9 (MAPK9)
Inactive — 0.0%DFG-inαC-out
Resolution
2.15 Å
R-value
0.286
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms8
Missing residues10
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MSKSKVDNQFYSVEVADSTFTVLKRYQQLKPIAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGTRYYRAPEVILGMGYAANVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDEHAIEEWKELIYKEVMDWE
UniProt reference sequence
YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
Aligned reference sequence
YQQL----------------KPIGSGA----------------QGIVCAAFD--TV------------------------------------LGINVAVKKLS--RPFQNQTH--------------------------AKRAYRELVLLKCV--------------------------NHKNIISLLNVFTPQK--TLEEFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVMELMD---------------ANLCQVIHM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELDHERMSYLLYQMLCGIKHLHSA---------------------------------------------GIIHRDL-----KPSNIVVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCTLKILDFGLARTACTNFMM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYVVTRYYRAPEVILG--------------------------------MGYK-ENVDIWSVGCIMGELVKG-----------------CVIFQG--------------------------------------------------TDHIDQWNKVIEQ--LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKT------------------------------------------------------------SQARDLLSKMLVIDPDKRIS--------------VDEALRHPYI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQQL----------------KPI---A----------------QGIVCAAFD--TV------------------------------------LGINVAVKKLS--RPFQNQTH--------------------------AKRAYRELVLLKCV--------------------------NHKNIISLLNVFTPQK--TLEEFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVMELM--------------------QVIHM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELDHERMSYLLYQMLCGIKHLHSA---------------------------------------------GIIHRDL-----KPSNIVVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCTLKILDFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRYYRAPEVILG--------------------------------MGYA-ANVDIWSVGCIMGELVKG-----------------CVIFQG--------------------------------------------------TDHIDQWNKVIEQ--LGTPSAEFMAALQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKT------------------------------------------------------------SQARDLLSKMLVIDPDKRIS--------------VDEALRHPYI
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRYYRAPE
Binding pocket
KPI___AQGIVCAVAVKKLRAYRELVLLKCVNKNIISLLNVYLVMELM______QVIHMHLHSAGIIHRDLKPSNIVVILDFG__
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7CML, Chain A