7CGA Chain A
Mitogen-activated protein kinase 12 (MAPK12)
Inactive — 31.6%DFG-inαC-in
Resolution
3.15 Å
R-value
0.163
Predicted activity confidence31.6%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NASGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKP
UniProt reference sequence
YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF
Aligned reference sequence
YRDL----------------QPVGSGA----------------YGAVCSAVD--GR------------------------------------TGAKVAIKKLY--RPFQSELF--------------------------AKRAYRELRLLKHM--------------------------RHENVIGLLDVFTPDE--TLDDFT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFYLVMPFMG---------------TDLGKLMKH--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLGEDRIQFLVYQMLKGLRYIHAA---------------------------------------------GIIHRDL-----KPGNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLARQADSEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVVTRWYRAPEVILN--W-----------------------------MRYT-QTVDIWSVGCIMAEMITG-----------------KTLFKG--------------------------------------------------SDHLDQLKEIMKV--TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS-----------------------------------------------------------------------PLAVNLLEKMLVLDAEQRVT--------------AGEALAHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRDL----------------QPVGSGA----------------YGAVCSAVD--GR------------------------------------TGAKVAIKKLY--RPFQSELF--------------------------AKRAYRELRLLKHM--------------------------RHENVIGLLDVFTPDE--TLDDFT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFYLVMPFMG---------------TDLGKLMKH--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLGEDRIQFLVYQMLKGLRYIHAA---------------------------------------------GIIHRDL-----KPGNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLARQADSEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVVTRWYRAPEVILN--W-----------------------------MRYT-QTVDIWSVGCIMAEMITG-----------------KTLFKG--------------------------------------------------SDHLDQLKEIMKV--TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS-----------------------------------------------------------------------PLAVNLLEKMLVLDAEQRVT--------------AGEALAHPYF
Activation segment
DFGLARQADSEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVVTRWYRAPE
Binding pocket
QPVGSGAYGAVCSVAIKKLRAYRELRLLKHMRENVIGLLDVYLVMPFMG_TDLGKLMKHYIHAAGIIHRDLKPGNLAVILDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7CGA, Chain A