7BL1 Chain C
Phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4)
Inactive — 31.6%DFG-outαC-out
Resolution
9.8 Å
R-value
0.157
Predicted activity confidence31.6%
Structure info
Alternate conformation—
Missing atoms261
Missing residues0
Salt bridge (KinCore)—
Sequence info
PDB sequence
—
UniProt reference sequence
FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDYLKQQRG
Aligned reference sequence
FEYD----------------KSLGSTR----------------FFKVARAKH----------------------------------------REGLVVVKVFA--IQDPTLPLTS------------------------YKQELEELKIRLNS--AQN---------------------CLPFQKASEKASEK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAMLFRQYVRD--------------NLYDRISTR--P--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLNNIEKRWIAFQILTAVDQAHKS---------------------------------------------GVRHGDI-----KTENVMVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WNWVLLTDFASFKPTYLPEDN--PADFNYFFD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSRRRTCYIAPERFVD--GGMFATELEYMRDPSTPLVDLNSNQRTR--GELK-RAMDIFSAGCVIAELFTE--G--------------VPLFDL------------------------------------------------------SQLLAYRNG--HFFPEQVLNKIED--------------------------------------------------------------------------------------------------HSIRELVTQMIHREPDKRLE--------------AEDYLKQQRG
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
—
Activation segment
—
Binding pocket
EKVGKGMFGELKRLAVKIEELKQEIALKDLGPLVILVSVELILEYLSNDSVAEALRTFLGLLHEMVKPENILLLSDFGLQ
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7BL1, Chain C