7BE6 Chain A
Epithelial discoidin domain-containing receptor 1 (DDR1)
Inactive — 0.1%DFG-outαC-inType2 · TJW
Resolution
1.87082 Å
R-value
0.189
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms2
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
MPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNT
UniProt reference sequence
LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE
Aligned reference sequence
LRFK----------------EKLGEGQ----------------FGEVHLCEV--DSPQDLVSLDFPLNVRKG--------------------HPLLVAVKILR--PDATKNA---------------------------RNDFLKEVKIMSRL--------------------------KDPNIIRLLGVCVQDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCMITDYMEN--------------GDLNQFLSA--HQLEDKAAEGAPGDGQAAQGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TISYPMLLHVAAQIASGMRYLATL---------------------------------------------NFVHRDL-----ATRNCLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFTIKIADFGMSRNLYAGDYY--RVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMAWECILM--------------------------------GKFT-TASDVWAFGVTLWEVLML--CR-------------AQPFGQ--------------------------------------------------LTDEQVIENAGEF--FRDQGRQVYLSRPPACP----------------------------------------------------------------------------------------------QGLYELMLRCWSRESEQRPP--------------FSQLHRFLAE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRFK----------------EKLGEGQ----------------FGEVHLCEV--DSPQDLVSLDFPLNVRKG--------------------HPLLVAVKILR--PDATKNA---------------------------RNDFLKEVKIMSRL--------------------------KDPNIIRLLGVCVQDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCMITDYMEN--------------GDLNQFLSA--HQLEDKAA-----------GP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TISYPMLLHVAAQIASGMRYLATL---------------------------------------------NFVHRDL-----ATRNCLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFTIKIADFGMSRNLYAGDYY--RVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMAWECILM--------------------------------GKFT-TASDVWAFGVTLWEVLML--CR-------------AQPFGQ--------------------------------------------------LTDEQVIENAGEF--FRDQGRQVYLSRPPACP----------------------------------------------------------------------------------------------QGLYELMLRCWSRESEQRPP--------------FSQLHRFLAE
Activation segment
DFGMSRNLYAGDYY--RVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMAWE
Binding pocket
EKLGEGQFGEVHLVAVKILDFLKEVKIMSRLKPNIIRLLGVCMITDYMENGDLNQFLSAYLATLNFVHRDLATRNCLVIADFGMS
Ligand info
Orthosteric ligand
TJW
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7BE6, Chain A