7B5Q Chain J
Cyclin-dependent kinase 7 (CDK7)
Active — 99.9%DFG-inαC-inType1 · I74
Resolution
2.5 Å
R-value
999.0
Predicted activity confidence99.9%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPN
UniProt reference sequence
YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
Aligned reference sequence
YEKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKKIK--LGHRSEAKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKKIK--L-----AKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Activation segment
DFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPE
Binding pocket
DFLGEGQFATVYKVAIKKITALREIKLLQELSPNIIGLLDASLVFDFME_TDLEVIIKDYLHQHWILHRDLKPNNLLLLADFGLA
Ligand info
Orthosteric ligand
I74
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7B5Q, Chain J