7B36 Chain C
Serine/threonine-protein kinase 26 (STK26)
Inactive — 0.0%DFG-inαC-inType1.5_Back · 59T
Resolution
2.10681 Å
R-value
0.203
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms18
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
IADPEELFTKLERIGKFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAVGTPFWMAPEVIQQSYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGH
UniProt reference sequence
FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI
Aligned reference sequence
FTKL----------------ERIGKGS----------------FGEVFKGID--NR------------------------------------TQQVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSSYVTKYYGSYLKGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLRA--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFDEFQIATMLKEILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGDVKLADFGVAGQLTDTQIK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIQQ--------------------------------SAYD-SKADIWSLGITAIELAKG-----------------EPPNSD--------------------------------------------------MHPMRVLFLIPKN--NPPTLVGDFT-----------------------------------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT--------------AKELLKHKFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTKL----------------ERIGK------------------FGEVFKGID--NR------------------------------------TQQVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSSYVTKYYGSYLKGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLRA--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFDEFQIATMLKEILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGDVKLADFGVA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTPFWMAPEVIQQ--------------------------------S-YD-SKADIWSLGITAIELAKG-----------------EPPNSD--------------------------------------------------MHPMRVLFLIPKN--NPPTLVGDFT-----------------------------------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT--------------AKELLKHKFI
Activation segment
DFGVA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGTPFWMAPE
Binding pocket
ERIGK__FGEVFKVAIKIIDIQQEITVLSQCDSYVTKYYGSWIIMEYLGGGSALDLLRAYLHSEKKIHRDIKAANVLLLADFGVA
Ligand info
Orthosteric ligand
59T
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7B36, Chain C