7B36 Chain A
Serine/threonine-protein kinase 26 (STK26)
Inactive — 0.0%DFG-inαC-inType1.5_Front · 59T
Resolution
2.10681 Å
R-value
0.203
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms17
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ADPEELFTKLERIGKSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS
UniProt reference sequence
FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI
Aligned reference sequence
FTKL----------------ERIGKGS----------------FGEVFKGID--NR------------------------------------TQQVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSSYVTKYYGSYLKGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLRA--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFDEFQIATMLKEILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGDVKLADFGVAGQLTDTQIK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIQQ--------------------------------SAYD-SKADIWSLGITAIELAKG-----------------EPPNSD--------------------------------------------------MHPMRVLFLIPKN--NPPTLVGDFT-----------------------------------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT--------------AKELLKHKFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTKL----------------ERIGK-S----------------FGEVFKGID--NR------------------------------------TQQVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSSYVTKYYGSYLKGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLRA--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFDEFQIATMLKEILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGDVKLADFGVA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPFWMAPEVIQQ--------------------------------SAYD-SKADIWSLGITAIELAKG-----------------EPPNSD--------------------------------------------------MHPMRVLFLIPKN--NPPTLVGDFT-----------------------------------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT--------------AKELLKHKFI
Activation segment
DFGVA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTPFWMAPE
Binding pocket
ERIGK_SFGEVFKVAIKIIDIQQEITVLSQCDSYVTKYYGSWIIMEYLGGGSALDLLRAYLHSEKKIHRDIKAANVLLLADFGVA
Ligand info
Orthosteric ligand
59T
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7B36, Chain A