7AYM Chain A
Discoidin domain-containing receptor 2 (DDR2)
Inactive — 0.0%DFG-outαC-inType2 · 4VD
Resolution
2.12 Å
R-value
0.239
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GPRVDFPRKLLTFKEKLGEGFGEVHLCEVEGMSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHQPTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYELMLSCWRRDTKNRPSFQEIHRLL
UniProt reference sequence
LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQ
Aligned reference sequence
LTFK----------------EKLGEGQ----------------FGEVHLCEV--EGMEKFKDKDFALDVSAN--------------------QPVLVAVKMLR--ADANKNA---------------------------RNDFLKEIKIMSRL--------------------------KDPNIIHLLAVCITDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCMITEYMEN--------------GDLNQFLSR--HEPPNSSSSDVR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVSYTNLKFMATQIASGMKYLSSL---------------------------------------------NFVHRDL-----ATRNCLVGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYTIKIADFGMSRNLYSGDYY--RIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMSWESILL--------------------------------GKFT-TASDVWAFGVTLWETFTF--CQ-------------EQPYSQ--------------------------------------------------LSDEQVIENTGEF--FRDQGRQTYLPQPAICP----------------------------------------------------------------------------------------------DSVYKLMLSCWRRDTKNRPS--------------FQEIHLLLLQ
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTFK----------------EKLGEG-----------------FGEVHLCEV--EGM------------SAN--------------------QPVLVAVKMLR--ADANKNA---------------------------RNDFLKEIKIMSRL--------------------------KDPNIIHLLAVCITDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLCMITEYMEN--------------GDLNQFLSR--HQP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVSYTNLKFMATQIASGMKYLSSL---------------------------------------------NFVHRDL-----ATRNCLVGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYTIKIADFGMSRNLYSGDYY--RIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMSWESILL--------------------------------GKFT-TASDVWAFGVTLWETFTF--CQ-------------EQPYSQ--------------------------------------------------LSDEQVIENTGEF--FRDQGRQTYLPQPAICP----------------------------------------------------------------------------------------------DSVYELMLSCWRRDTKNRPS--------------FQEIHRLL--
Activation segment
DFGMSRNLYSGDYY--RIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRAVLPIRWMSWE
Binding pocket
EKLGEG_FGEVHLVAVKMLDFLKEIKIMSRLKPNIIHLLAVCMITEYMENGDLNQFLSRYLSSLNFVHRDLATRNCLVIADFGMS
Ligand info
Orthosteric ligand
4VD
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7AYM, Chain A