7AW2 Chain A
Tyrosine-protein kinase Mer (MERTK)
Inactive — 0.1%DFG-inαC-outType1.5_Front · S4W
Resolution
2.1 Å
R-value
0.208
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms14
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
SHMEELQNKLEDVVIDRNLLILGRILGEFGSVMEGNLKQEDGTSLKVAVKTMKNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSPKPMVILPFMKYGDLHTYLLYSRLETGPRHIPLQTLLRFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLERLLESLP
UniProt reference sequence
LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK
Aligned reference sequence
LILG----------------KILGEGE----------------FGSVMEGNL--KQEDG---------------------------------TSLKVAVKTMK--LDNSSQRE--------------------------IEEFLSEAACMKDF--------------------------SHPNVIRLLGVCIEMS--SQGIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLKFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGLSKKIYSGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIAKMPVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LILG----------------RIL--GE----------------FGSVMEGNL--KQEDG---------------------------------TSLKVAVKTMK----NSSQRE--------------------------IEEFLSEAACMKDF--------------------------SHPNVIRLLGVCIEMS--S---P-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPFMKY--------------GDLHTYLLY--SRLETGPR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIPLQTLLRFMVDIALGMEYLSNR---------------------------------------------NFLHRDL-----AARNCMLRD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIESLAD--------------------------------RVYT-SKSDVWAFGVTMWEIATR--G--------------MTPYPG--------------------------------------------------VQNHEMYDYLLHG--HRLKQPEDCL-----------------------------------------------------------------------------------------------------DELYEIMYSCWRTDPLDRPT--------------FSVLRLQLEP
Activation segment
DFGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWIAIE
Binding pocket
RILGE__FGSVMEVAVKTMEFLSEAACMKDFSPNVIRLLGVMVILPFMKYGDLHTYLLYYLSNRNFLHRDLAARNCMLVADFGL_
Ligand info
Orthosteric ligand
S4W
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7AW2, Chain A