7A22 Chain A
Casein kinase II subunit alpha' (CSNK2A2)
Active — 100.0%DFG-inαC-inType1 · QWW
Resolution
1.01 Å
R-value
0.138
Predicted activity confidence100.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQS
UniProt reference sequence
YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF
Aligned reference sequence
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNERVVVKILK--PVK-------------------------------KKKIKREVKILENL--R-----------------------GGTNIIKLIDTVKDPV--SK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEYINN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILTDFDIRFYMYELLKALDYCHSK---------------------------------------------GIMHRDV-----KPHNVMIDH--Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKKLRLIDWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--R--------------EPFFHG--------------------------------------------------QDNYDQLVRIAKV--LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS-----------------------------------------------------------------PEALDLLDKLLRYDHQQRLT--------------AKEAMEHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLV----------------RKLGRGK----------------YSEVFEAIN--IT------------------------------------NNERVVVKILK--PVK-------------------------------KKKIKREVKILENL--R-----------------------GGTNIIKLIDTVKDPV--SK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPALVFEYINN--------------TDFKQLYQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILTDFDIRFYMYELLKALDYCHSK---------------------------------------------GIMHRDV-----KPHNVMIDH--Q-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QKKLRLIDWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPELLVD--Y-----------------------------QMYD-YSLDMWSLGCMLASMIFR--R--------------EPFFHG--------------------------------------------------QDNYDQLVRIAKV--LGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS-----------------------------------------------------------------PEALDLLDKLLRYDHQQRLT--------------AKEAMEHPYF
Activation segment
DWGLAEFYHPAQEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRVASRYFKGPE
Binding pocket
RKLGRGKYSEVFEVVVKILKIKREVKILENLRTNIIKLIDTALVFEYIN_NTDFKQLYQYCHSKGIMHRDVKPHNVMILIDWGLA
Ligand info
Orthosteric ligand
QWW
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 7A22, Chain A