6ZIW Chain I
Interleukin-1 receptor-associated kinase 3 (IRAK3)
Inactive — 46.6%DFG-inαC-inATPlike · AGS
Resolution
2.18 Å
R-value
0.218
Predicted activity confidence46.6%
Structure info
Alternate conformation—
Missing atoms20
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKCKKHWKRFLSELEVLLLFHHPNILELAAYFTFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLY
UniProt reference sequence
EGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES
Aligned reference sequence
EGT---RNFHKD--------FLIGEGE----------------IFEVYRVEI----------------------------------------QNLTYAVKLFK--QEKKMQCKKH------------------------WKRFLSELEVLLLF--------------------------HHPNILELAAYFTETE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFCLIYPYMRN--------------GTLFDRLQC--VGDTA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWHIRIGILIGISKAIHYLHNV--QPC----------------------------------------SVICGSI-----SSANILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFQPKLTDFAMAHFRSHLEHQ--SCTINMT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSSSKHLWYMPEEYIRQ--------------------------------GKLS-IKTDVYSFGIVIMEVLTG-----------------CRVVLD--DPKH--------------------------------------------IQLRDLLRELMEK--RGLDSCLSFLDKKVPPCPRNFS-----------------------------------------------------------------------------------------AKLFCLAGRCAATRAKLRPS--------------MDEVLNTLES
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
EGT---RNFHKD--------FLIGEGE----------------IFEVYRVEI----------------------------------------QNLTYAVKLFK--------CKKH------------------------WKRFLSELEVLLLF--------------------------HHPNILELAAYFT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCLIYPYMRN--------------GTLFDRLQC--VGDTA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLPWHIRIGILIGISKAIHYLHNV--QPC----------------------------------------SVICGSI-----SSANILLDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFQPKLTDFAMAHFR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LWYMPEEYIRQ--------------------------------GKLS-IKTDVYSFGIVIMEVLTG-----------------CRVVLD-----H--------------------------------------------IQLRDLLRELMEK--RGLDSCLSFLDKKVPPCPRNFS-----------------------------------------------------------------------------------------AKLFCLAGRCAATRAKLRPS--------------MDEVLNTLES
Activation segment
DFAMAHFR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LWYMPEE
Binding pocket
FLIGEGEIFEVYRYAVKLFRFLSELEVLLLFHPNILELAAYCLIYPYMRNGTLFDRLQCNVQPCSVICGSISSANILLLTDFAMA
Ligand info
Orthosteric ligand
AGS
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6ZIW, Chain I