6ZCQ Chain A
Tyrosine-protein kinase SYK (SYK)
Active — 100.0%DFG-inαC-inType1 · QFB
Resolution
2.32 Å
R-value
0.191
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms17
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKLKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNHH
UniProt reference sequence
LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN
Aligned reference sequence
LTLE--D-------------KELGSGN----------------FGTVKKGYY--QMKK----------------------------------VVKTVAVKILK--NEANDPAL--------------------------KDELLAEANVMQQL--------------------------DNPYIVRMIGICEAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SWMLVMEMAEL--------------GPLNKYLQQ--NR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVKDKNIIELVHQVSMGMKYLEES---------------------------------------------NFVHRDL-----AARNVLLVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QHYAKISDFGLSKALRADENY--YKAQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THGKWPVKWYAPECINY--------------------------------YKFS-SKSDVWSFGVLMWEAFSY--G--------------QKPYRG--------------------------------------------------MKGSEVTAMLEKG--ERMGCPAGCP-----------------------------------------------------------------------------------------------------REMYDLMNLCWTYDVENRPG--------------FAAVELRLRN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLE--D-------------KELGSGN----------------FGTVKKGYY--QMKK----------------------------------VVKTVAVKILK---------L--------------------------KDELLAEANVMQQL--------------------------DNPYIVRMIGICEAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SWMLVMEMAEL--------------GPLNKYLQQ--NR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVKDKNIIELVHQVSMGMKYLEES---------------------------------------------NFVHRDL-----AARNVLLVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QHYAKISDFGLSKALRADENY--YKAQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TH-KWPVKWYAPECINY--------------------------------YKFS-SKSDVWSFGVLMWEAFSY--G--------------QKPYRG--------------------------------------------------MKGSEVTAMLEKG--ERMGCPAGCP-----------------------------------------------------------------------------------------------------REMYDLMNLCWTYDVENRPG--------------FAAVELRLRN
Activation segment
DFGLSKALRADENY--YKAQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TH-KWPVKWYAPE
Binding pocket
KELGSGNFGTVKKVAVKILELLAEANVMQQLDPYIVRMIGIMLVMEMAELGPLNKYLQQYLEESNFVHRDLAARNVLLISDFGLS
Ligand info
Orthosteric ligand
QFB
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6ZCQ, Chain A