6Z36 Chain B
Activin receptor type-1 (ACVR1)
Active — 92.4%DFG-inαC-inType1 · Q5Z
Resolution
1.37 Å
R-value
0.151
Predicted activity confidence92.4%
Structure info
Alternate conformationA
Missing atoms8
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI
UniProt reference sequence
ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTK
Aligned reference sequence
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFG--GKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Activation segment
DLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPE
Binding pocket
ECVGKGRYGEVWRVAVKIFSWFRETELYNTVMENILGFIASWLITHYHEMGSLYDYLQL__GKPAIAHRDLKSKNILVIADLGLA
Ligand info
Orthosteric ligand
Q5Z
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6Z36, Chain B