6YXV Chain D
Focal adhesion kinase 1 (PTK2)
Inactive — 0.0%DFG-inαC-inType1 · Q2H
Resolution
2.298 Å
R-value
0.203
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ
UniProt reference sequence
IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST
Aligned reference sequence
IELG----------------RCIGEGQ----------------FGDVHQGIY--MSPEN---------------------------------PALAVAIKTCK--NCTSDSV---------------------------REKFLQEALTMRQF--------------------------DHPHIVKLIGVITEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVWIIMELCTL--------------GELRSFLQV--RKY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDLASLILYAYQLSTALAYLESK---------------------------------------------RFVHRDI-----AARNVLVSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDCVKLGDFGLSRYMEDSTYY--KA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKGKLPIKWMAPESINF--------------------------------RRFT-SASDVWMFGVCMWEILMH--G--------------VKPFQG--------------------------------------------------VKNNDVIGRIENG--ERLPMPPNCP-----------------------------------------------------------------------------------------------------PTLYSLMTKCWAYDPSRRPR--------------FTELKAQLST
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IELG----------------RCIGEGQ----------------FGDVHQGIY--MSPEN---------------------------------PALAVAIKTCK--NCTSDSV---------------------------REKFLQEALTMRQF--------------------------DHPHIVKLIGVITEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVWIIMELCTL--------------GELRSFLQV--RKY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDLASLILYAYQLSTALAYLESK---------------------------------------------RFVHRDI-----AARNVLVSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDCVKLGDFGLS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPIKWMAPESINF--------------------------------RRFT-SASDVWMFGVCMWEILMH--G--------------VKPFQG--------------------------------------------------VKNNDVIGRIENG--ERLPMPPNCP-----------------------------------------------------------------------------------------------------PTLYSLMTKCWAYDPSRRPR--------------FTELKAQLST
Activation segment
DFGLS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPIKWMAPE
Binding pocket
RCIGEGQFGDVHQVAIKTCKFLQEALTMRQFDPHIVKLIGVWIIMELCTLGELRSFLQVYLESKRFVHRDIAARNVLVLGDFGLS
Ligand info
Orthosteric ligand
Q2H
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YXV, Chain D