6YVY Chain A
Focal adhesion kinase 1 (PTK2)
Inactive — 4.3%DFG-inαC-inType1 · P1E
Resolution
1.918 Å
R-value
0.215
Predicted activity confidence4.3%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
TRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ
UniProt reference sequence
IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST
Aligned reference sequence
IELG----------------RCIGEGQ----------------FGDVHQGIY--MSPEN---------------------------------PALAVAIKTCK--NCTSDSV---------------------------REKFLQEALTMRQF--------------------------DHPHIVKLIGVITEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVWIIMELCTL--------------GELRSFLQV--RKY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDLASLILYAYQLSTALAYLESK---------------------------------------------RFVHRDI-----AARNVLVSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDCVKLGDFGLSRYMEDSTYY--KA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKGKLPIKWMAPESINF--------------------------------RRFT-SASDVWMFGVCMWEILMH--G--------------VKPFQG--------------------------------------------------VKNNDVIGRIENG--ERLPMPPNCP-----------------------------------------------------------------------------------------------------PTLYSLMTKCWAYDPSRRPR--------------FTELKAQLST
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IELG----------------RCIGEGQ----------------FGDVHQGIY--MSPEN---------------------------------PALAVAIKTCK--NCTSDSV---------------------------REKFLQEALTMRQF--------------------------DHPHIVKLIGVITEN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVWIIMELCTL--------------GELRSFLQV--RKY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDLASLILYAYQLSTALAYLESK---------------------------------------------RFVHRDI-----AARNVLVSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDCVKLGDFGLSRYM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKLPIKWMAPESINF--------------------------------RRFT-SASDVWMFGVCMWEILMH--G--------------VKPFQG--------------------------------------------------VKNNDVIGRIENG--ERLPMPPNCP-----------------------------------------------------------------------------------------------------PTLYSLMTKCWAYDPSRRPR--------------FTELKAQLST
Activation segment
DFGLSRYM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKLPIKWMAPE
Binding pocket
RCIGEGQFGDVHQVAIKTCKFLQEALTMRQFDPHIVKLIGVWIIMELCTLGELRSFLQVYLESKRFVHRDIAARNVLVLGDFGLS
Ligand info
Orthosteric ligand
P1E
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YVY, Chain A