6YTA Chain A
Dual specificity protein kinase CLK1 (CLK1)
Active — 95.4%DFG-inαC-inType1 · IYZ
Resolution
2.3 Å
R-value
0.194
Predicted activity confidence95.4%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKS
UniProt reference sequence
YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF
Aligned reference sequence
YEIV----------------DTLGEGA----------------FGKVVECID--HKA-----------------------------------GGRHVAVKIVK--NVDRY-----------------------------CEAARSEIQVLEHL--NTTDPN------------------STFRCVQMLEWFEHHG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICIVFELLG---------------LSTYDFIKE--NGFL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFRLDHIRKMAYQICKSVNFLHSN---------------------------------------------KLTHTDL-----KPENILFVQ--SDYTEAYNPKIKRDERTLI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPDIKVVDFGSATYDDEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STLVSTRHYRAPEVILA--------------------------------LGWS-QPCDVWSIGCILIEYYLG-----------------FTVFPT--------------------------------------------------HDSKEHLAMMERI--LGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEH----------------------------------------------------------ERLFDLIQKMLEYDPAKRIT--------------LREALKHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEIV----------------DTLGEGA----------------FGKVVECID--HKA-----------------------------------GGRHVAVKIVK--NVDRY-----------------------------CEAARSEIQVLEHL--NTTDPN------------------STFRCVQMLEWFEHHG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICIVFELLG---------------LSTYDFIKE--NGFL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFRLDHIRKMAYQICKSVNFLHSN---------------------------------------------KLTHTDL-----KPENILFVQ--SDYTEAYNPKIKRDERTLI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPDIKVVDFGSATYDDEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STLVSTRHYRAPEVILA--------------------------------LGWS-QPCDVWSIGCILIEYYLG-----------------FTVFPT--------------------------------------------------HDSKEHLAMMERI--LGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEH----------------------------------------------------------ERLFDLIQKMLEYDPAKRIT--------------LREALKHPFF
Activation segment
DFGSATYDDEHH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STLVSTRHYRAPE
Binding pocket
DTLGEGAFGKVVEVAVKIVAARSEIQVLEHLNFRCVQMLEWCIVFELLG_LSTYDFIKEFLHSNKLTHTDLKPENILFVVDFGSA
Ligand info
Orthosteric ligand
IYZ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YTA, Chain A