6YLL Chain B
Mitogen-activated protein kinase 6 (MAPK6)
Inactive — 0.0%DFG-inαC-in
Resolution
2.89 Å
R-value
0.246
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues15
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
VAIKKISVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSF
UniProt reference sequence
YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
Aligned reference sequence
YMDL----------------KPLGCGG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV--LTDPQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQLTDDVGSLTELN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFGLARIMDPHYSH--KGHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REALDFLEQILTFSPMDRLT--------------AEEALSHPYM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
------------------------------------------------------------------------------------------------VAIKKI--------S----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDF---------------GHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REAVDFLEQILTFSPMDRLT--------------AEEALSHPYM
Activation segment
DF---------------GHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPR
Binding pocket
_____________VAIKKIHALREIKIIRRLDDNIVKVFEIYIVQEYME_TDLANVLEQYIHSANVLHRDLKPANLFIIGDFG__
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YLL, Chain B