6YLL Chain A
Mitogen-activated protein kinase 6 (MAPK6)
Active — 96.1%DFG-inαC-inType1 · OYB
Resolution
2.89 Å
R-value
0.246
Predicted activity confidence96.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
FDLGSRYMDLKPLGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYSF
UniProt reference sequence
YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
Aligned reference sequence
YMDL----------------KPLGCGG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV--LTDPQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQLTDDVGSLTELN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFGLARIMDPHYSH--KGHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REALDFLEQILTFSPMDRLT--------------AEEALSHPYM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YMDL----------------KPL--GG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV--LTDPQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQLTD-----TELN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFGLARIM----------HL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REAVDFLEQILTFSPMDRLT--------------AEEALSHPYM
Activation segment
DFGLARIM----------HL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPR
Binding pocket
KPL__GGNGLVFSVAIKKIHALREIKIIRRLDDNIVKVFEIYIVQEYME_TDLANVLEQYIHSANVLHRDLKPANLFIIGDFGLA
Ligand info
Orthosteric ligand
OYB
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YLL, Chain A