6YLC Chain C
Mitogen-activated protein kinase 6 (MAPK6)
Inactive — 5.4%DFG-inαC-inType1 · OXW
Resolution
2.43 Å
R-value
0.191
Predicted activity confidence5.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIY
UniProt reference sequence
YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
Aligned reference sequence
YMDL----------------KPLGCGG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV--LTDPQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQLTDDVGSLTELN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFGLARIMDPHYSH--KGHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REALDFLEQILTFSPMDRLT--------------AEEALSHPYM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YMDL----------------KPLGCGG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV--LTDPQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQL--------ELN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFG----------------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSV----IRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REAVDFLEQILTFSPMDRLT--------------AEEALSHPYM
Activation segment
DFG----------------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPR
Binding pocket
KPLGCGGNGLVFSVAIKKIHALREIKIIRRLDDNIVKVFEIYIVQEYME_TDLANVLEQYIHSANVLHRDLKPANLFIIGDFG__
Ligand info
Orthosteric ligand
OXW
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YLC, Chain C