6YLC Chain A
Mitogen-activated protein kinase 6 (MAPK6)
Inactive — 0.0%DFG-outαC-inType1 · OXW
Resolution
2.43 Å
R-value
0.191
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYS
UniProt reference sequence
YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
Aligned reference sequence
YMDL----------------KPLGCGG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV--LTDPQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQLTDDVGSLTELN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFGLARIMDPHYSH--KGHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REALDFLEQILTFSPMDRLT--------------AEEALSHPYM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YMDL----------------KPLGCGG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV-----PQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFGLARIM-----------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REAVDFLEQILTFSPMDRLT--------------AEEALSHPYM
Activation segment
DFGLARIM-----------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPR
Binding pocket
KPLGCGGNGLVFSVAIKKIHALREIKIIRRLDDNIVKVFEIYIVQEYME_TDLANVLEQYIHSANVLHRDLKPANLFIIGDFGLA
Ligand info
Orthosteric ligand
OXW
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YLC, Chain A