6YKY Chain C
Mitogen-activated protein kinase 6 (MAPK6)
Active — 67.4%DFG-inαC-inType1 · OWQ
Resolution
2.52 Å
R-value
0.201
Predicted activity confidence67.4%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIY
UniProt reference sequence
YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM
Aligned reference sequence
YMDL----------------KPLGCGG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV--LTDPQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQLTDDVGSLTELN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFGLARIMDPHYSH--KGHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REALDFLEQILTFSPMDRLT--------------AEEALSHPYM
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YMDL----------------KPLGCGG----------------NGLVFSAVD--ND------------------------------------CDKRVAIKKIV--L-DPQS----------------------------VKHALREIKIIRRL--------------------------DHDNIVKVFEILGPSG--SQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYIVQEYME---------------TDLANVLEQ--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLLEEHARLFMYQLLRGLKYIHSA---------------------------------------------NVLHRDL-----KPANLFINT--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLVLKIGDFGLARIM-----------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPRLLLS--P-----------------------------NNYT-KAIDMWAAGCIFAEMLTG-----------------KTLFAG--------------------------------------------------AHELEQMQLILES--IPVVHEEDRQELLSVIP---RNDMTEPHKPLTQLLPGIS------------------------------------------------------------------------REAVDFLEQILTFSPMDRLT--------------AEEALSHPYM
Activation segment
DFGLARIM-----------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEGLVTKWYRSPR
Binding pocket
KPLGCGGNGLVFSVAIKKIHALREIKIIRRLDDNIVKVFEIYIVQEYME_TDLANVLEQYIHSANVLHRDLKPANLFIIGDFGLA
Ligand info
Orthosteric ligand
OWQ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YKY, Chain C