6YI8 Chain A
Fibroblast growth factor receptor 4 (FGFR4)
Inactive — 0.3%DFG-inαC-inType1 · FGF
Resolution
2.13 Å
R-value
0.198
Predicted activity confidence0.3%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE
UniProt reference sequence
LVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDK
Aligned reference sequence
LVLG----------------KPLGEGC----------------FGQVVRAEA--FGMDPARPD-----------------------------QASTVAVKMLK--DNASDKD---------------------------LADLVSEMEVMKLI--G-----------------------RHKNIINLLGVCTQEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVECAAK--------------GNLREFLRA--RRPPGPDLSPDGPRSSEG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSFPVLVSCAYQVARGMQYLESR---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLARGVHHIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGILLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFSLLREG--HRMDRPPHCP-----------------------------------------------------------------------------------------------------PELYGLMRECWHAAPSQRPT--------------FKQLVEALDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LVLG----------------KPLGEGC----------------FGQVVRAEA--FGMDPARPD-----------------------------QASTVAVKMLK--DNASDKD---------------------------LADLVSEMEVMKLI--G-----------------------RHKNIINLLGVCTQEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVECAAK--------------GNLREFLRA--RRPPGPDLS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSFPVLVSCAYQVARGMQYLESR---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVMKIADFGLA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGILLWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFSLLREG--HRMDRPPHCP-----------------------------------------------------------------------------------------------------PELYGLMRECWHAAPSQRPT--------------FKQLVEALDK
Activation segment
DFGLA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPVKWMAPE
Binding pocket
KPLGEGCFGQVVRVAVKMLDLVSEMEVMKLIGKNIINLLGVYVIVECAAKGNLREFLRAYLESRKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
FGF
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YI8, Chain A