6YGN Chain A
Titin (TTN)
Active — 96.5%DFG-inαC-in
Resolution
2.4 Å
R-value
0.174
Predicted activity confidence96.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKEDKTRAMNYDEEVDETREVSMTKASHSSTKELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIERVSTKVIRTLKHRRYYHTLIKKDLNMVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDY
UniProt reference sequence
YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWL
Aligned reference sequence
YMIA----------------EDLGRGE----------------FGIVHRCVE--TS------------------------------------SKKTYMAKFVK--VKGTD-----------------------------QVLVKKEISILNIA--------------------------RHRNILHLHESFESME--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELVMIFEFISG--------------LDIFERINT--SAF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELNEREIVSYVHQVCEALQFLHSH---------------------------------------------NIGHFDI-----RPENIIYQT--RR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSTIKIIEFGQARQLKPGDNF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLLFTAPEYYAPEVHQH--------------------------------DVVS-TATDMWSLGTLVYVLLSG-----------------INPFLA--------------------------------------------------ETNQQIIENIMNA--EYTFDEEAFKEIS--------------------------------------------------------------------------------------------------IEAMDFVDRLLVKERKSRMT--------------ASEALQHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YMIA----------------EDLGRGE----------------FGIVHRCVE--TS------------------------------------SKKTYMAKFVK--VKGTD-----------------------------QVLVKKEISILNIA--------------------------RHRNILHLHESFESME--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELVMIFEFISG--------------LDIFERINT--SAF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELNEREIVSYVHQVCEALQFLHSH---------------------------------------------NIGHFDI-----RPENIIYQT--RR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSTIKIIEFGQARQLKPGDNF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLLFTAPEYYAPEVHQH--------------------------------DVVS-TATDMWSLGTLVYVLLSG-----------------INPFLA--------------------------------------------------ETNQQIIENIMNA--EYTFDEEAFKEIS--------------------------------------------------------------------------------------------------IEAMDFVDRLLVKERKSRMT--------------ASEALQHPWL
Activation segment
EFGQARQLKPGDNF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLLFTAPEYYAPE
Binding pocket
EDLGRGEFGIVHRYMAKFVLVKKEISILNIARRNILHLHESVMIFEFISGLDIFERINTFLHSHNIGHFDIRPENIIYIIEFGQA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YGN, Chain A