6YA8 Chain A
Cell division cycle 7-related protein kinase (CDC7)
Active — 84.4%DFG-inαC-inATPlike,Allosteric · ADP
Resolution
1.79 Å
R-value
0.167
Predicted activity confidence84.4%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGAGGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM
UniProt reference sequence
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF
Aligned reference sequence
FKIE----------------DKIGEGT----------------FSSVYLATA--QLQVG---------------------------------PEEKIALKHLI--PTSH------------------------------PIRIAAELQCLTVA--G-----------------------GQDNVMGVKYCFRKND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVVIAMPYLEH--------------ESFLDILN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSFQEVREYMLNLFKALKRIHQF---------------------------------------------GIVHRDV-----KPSNFLYNR--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKYALVDFGLAQGTHDTKIE--LLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRAGTPGFRAPEVLTK--C-----------------------------PNQT-TAIDMWSAGVIFLSLLSG--R--------------YPFYKA--------------------------------------------------SDDLTALAQIMTI--RGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVP--DEAYDLLDKLLDLNPASRIT--------------AEEALLHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKIE----------------DKIGEGT----------------FSSVYLATA--QLQVG---------------------------------PEEKIALKHLI--PTSH------------------------------PIRIAAELQCLTVA--G-----------------------GQDNVMGVKYCFRKND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVVIAMPYLEH--------------ESFLDILN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSFQEVREYMLNLFKALKRIHQF---------------------------------------------GIVHRDV-----KPSNFLYNR--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKYALVDFGLAQGTHDTKIE--LLKFV-----------------------------------------------------------------------------------------------------------------------------------PASLTCDCYATDKVCSICLSRRQQV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRAGTPGFRAPEVLTK--C-----------------------------PNQT-TAIDMWSAGVIFLSLLSG--R--------------YPFYKA--------------------------------------------------SDDLTALAQIMTI--RGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRG----------------------------------------------------------------AGGWNEVP--DEAYDLLDKLLDLNPASRIT--------------AEEALLHPFF
Activation segment
DFGLAQGTHDTKIE--LLKFV-----------------------------------------------------------------------------------------------------------------------------------PASLTCDCYATDKVCSICLSRRQQV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRAGTPGFRAPE
Binding pocket
DKIGEGTFSSVYLIALKHLRIAAELQCLTVAGDNVMGVKYCVIAMPYLE_HESFLD__IRIHQFGIVHRDVKPSNFLYLVDFGLA
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YA8, Chain A