6YA6 Chain A
Cell division cycle 7-related protein kinase (CDC7)
Inactive — 0.2%DFG-inαC-inType1,Type1 · 0SX
Resolution
1.44 Å
R-value
0.168
Predicted activity confidence0.2%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGAGAGGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS
UniProt reference sequence
FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF
Aligned reference sequence
FKIE----------------DKIGEGT----------------FSSVYLATA--QLQVG---------------------------------PEEKIALKHLI--PTSH------------------------------PIRIAAELQCLTVA--G-----------------------GQDNVMGVKYCFRKND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVVIAMPYLEH--------------ESFLDILN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSFQEVREYMLNLFKALKRIHQF---------------------------------------------GIVHRDV-----KPSNFLYNR--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKYALVDFGLAQGTHDTKIE--LLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRAGTPGFRAPEVLTK--C-----------------------------PNQT-TAIDMWSAGVIFLSLLSG--R--------------YPFYKA--------------------------------------------------SDDLTALAQIMTI--RGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVP--DEAYDLLDKLLDLNPASRIT--------------AEEALLHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKIE----------------DKIGEGT----------------FSSVYLATA--QLQVG---------------------------------PEEKIALKHLI--PTSH------------------------------PIRIAAELQCLTVA--G-----------------------GQDNVMGVKYCFRKND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVVIAMPYLEH--------------ESFLDILN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLSFQEVREYMLNLFKALKRIHQF---------------------------------------------GIVHRDV-----KPSNFLYNR--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKKYALVDFGLAQGTHDTKIE--LLKFVQ----------------------------------------------------------------------------------------------------------------------------------PASLTCDCYATDKVCSICLSRRQQV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRAGTPGFRAPEVLTK--C-----------------------------PNQT-TAIDMWSAGVIFLSLLSG--R--------------YPFYKA--------------------------------------------------SDDLTALAQIMTI--RGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRG--------------------------------------------------------------AGAGGWNEVP--DEAYDLLDKLLDLNPASRIT--------------AEEALLHPFF
Activation segment
DFGLAQGTHDTKIE--LLKFVQ----------------------------------------------------------------------------------------------------------------------------------PASLTCDCYATDKVCSICLSRRQQV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APRAGTPGFRAPE
Binding pocket
DKIGEGTFSSVYLIALKHLRIAAELQCLTVAGDNVMGVKYCVIAMPYLE_HESFLD__IRIHQFGIVHRDVKPSNFLYLVDFGLA
Ligand info
Orthosteric ligand
0SX
Allosteric ligand
None
Ligand typeType1,Type1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6YA6, Chain A