6Y6H Chain A
Serine/threonine-protein kinase 17B (STK17B)
Active — 99.4%DFG-inαC-inType1 · OBW
Resolution
1.95 Å
R-value
0.183
Predicted activity confidence99.4%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSS
UniProt reference sequence
YILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWL
Aligned reference sequence
YILT--S-------------KELGRGK----------------FAVVRQCIS--KS------------------------------------TGQEYAAKFLK--KRRRGQDC--------------------------RAEILHEIAVLELA--K-----------------------SCPRVINLHEVYENTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIILILEYAAG--------------GEIFSLCLP--ELAE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQN---------------------------------------------NIVHLDL-----KPQNILLSS--IYP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGMSRKIGHACEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYLAPEILNY--------------------------------DPIT-TATDMWNIGIIAYMLLTH-----------------TSPFVG--------------------------------------------------EDNQETYLNISQV--NVDYSEETFSSVS--------------------------------------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT--------------AEICLSHSWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YILT--S-------------KELGRGK----------------FAVVRQCIS--KS------------------------------------TGQEYAAKFLK--KRRRGQDC--------------------------RAEILHEIAVLELA--K-----------------------SCPRVINLHEVYENTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIILILEYAAG--------------GEIFSLCLP--ELAE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQN---------------------------------------------NIVHLDL-----KPQNILLSS--IYP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGDIKIVDFGMSRKIGHACEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYLAPEILNY--------------------------------DPIT-TATDMWNIGIIAYMLLTH-----------------TSPFVG--------------------------------------------------EDNQETYLNISQV--NVDYSEETFSSVS--------------------------------------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT--------------AEICLSHSWL
Activation segment
DFGMSRKIGHACEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIMGTPEYLAPE
Binding pocket
KELGRGKFAVVRQYAAKFLEILHEIAVLELAKPRVINLHEVILILEYAAGGEIFSLCLPYLHQNNIVHLDLKPQNILLIVDFGMS
Ligand info
Orthosteric ligand
OBW
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6Y6H, Chain A