6XD3 Chain J
Cyclin-dependent kinase 7 (CDK7)
Active — 99.4%DFG-inαC-inType1 · V0G
Resolution
3.3 Å
R-value
999.0
Predicted activity confidence99.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNC
UniProt reference sequence
YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
Aligned reference sequence
YEKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKKIK--LGHRSEAKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFGSPNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEKL----------------DFLGEGQ----------------FATVYKARD--KN------------------------------------TNQIVAIKKIK--L-----AKDGI-----------------------NRTALREIKLLQEL--------------------------SHPNIIGLLDAFGHKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NISLVFDFME---------------TDLEVIIKD--NSLV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTPS-HIKAYMLMTLQGLEYLHQH---------------------------------------------WILHRDL-----KPNNLLLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGVLKLADFGLAKSFG-PNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPELLFG--A-----------------------------RMYG-VGVDMWAVGCILAELLLR-----------------VPFLPG--------------------------------------------------DSDLDQLTRIFET--LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG--------------------------------------------------------------------------DDLLDLIQGLFLFNPCARIT--------------ATQALKMKYF
Activation segment
DFGLAKSFG-PNRA--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------THQVVTRWYRAPE
Binding pocket
DFLGEGQFATVYKVAIKKITALREIKLLQELSPNIIGLLDASLVFDFME_TDLEVIIKDYLHQHWILHRDLKPNNLLLLADFGLA
Ligand info
Orthosteric ligand
V0G
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6XD3, Chain J