6X5Q Chain A
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
Inactive — 24.5%DFG-inαC-in
Resolution
2.14 Å
R-value
0.192
Predicted activity confidence24.5%
Structure info
Alternate conformation—
Missing atoms15
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYKQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR
UniProt reference sequence
YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI
Aligned reference sequence
YQLF----------------EELGKGA----------------FSVVRRCVK--VL------------------------------------AGQEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHPNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHYLIFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIQQILEAVLHCHQM---------------------------------------------GVVHRDL-----KPENLLLAS--KLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVEGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------DPYG-KPVDLWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHRLYQQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKDLINKMLTINPSKRIT--------------AAEALKHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQLF----------------EELGKGA----------------FSVVRRCVK--VL------------------------------------AGQEYAAKIIN--TKKLSARD--------------------------HQKLEREARICRLL--------------------------KHPNIVRLHDSISEEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHYLIFDLVTG--------------GELFEDIVA--RE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYSEADASHCIQQILEAVLHCHQM---------------------------------------------GVVHRNL-----KPENLLLAS--KLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAAVKLADFGLAIEVEGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPEVLRK--------------------------------DPYG-KPVDLWACGVILYILLVG-----------------YPPFWD--------------------------------------------------EDQHRLYKQIKAG--AYDFPSPEWDTVT--------------------------------------------------------------------------------------------------PEAKDLINKMLTINPSKRIT--------------AAEALKHPWI
Activation segment
DFGLAIEVEGEQQA--W---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGFAGTPGYLSPE
Binding pocket
EELGKGAFSVVRRYAAKIIKLEREARICRLLKPNIVRLHDSYLIFDLVTGGELFEDIVAHCHQMGVVHRNLKPENLLLLADFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6X5Q, Chain A