6WXJ Chain A
Macrophage colony-stimulating factor 1 receptor (CSF1R)
Inactive — 0.3%DFG-outαC-inType2 · UF4
Resolution
2.62 Å
R-value
0.185
Predicted activity confidence0.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
NSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGLPVKWMAPESIFDCVYTVQSDVWSYGILLWEFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQED
UniProt reference sequence
LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE
Aligned reference sequence
LQFG----------------KTLGAGA----------------FGKVVEATA--FGLGKED-------------------------------AVLKVAVKMLK--STAHADE---------------------------KEALMSELKIMSHL--G-----------------------QHENIVNLLGACTHGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVLVITEYCCY--------------GDLLNFLRR--KAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLELRDLLHFSSQVAQGMAFLASK---------------------------------------------NCIHRDV-----AARNVLLTN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHVAKIGDFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNARLPVKWMAPESIFD--------------------------------CVYT-VQSDVWSYGILLWEIFSL--G--------------LNPYPG--I-----------------------------------------------LVNSKFYKLVKDG--YQMAQPAFAP-----------------------------------------------------------------------------------------------------KNIYSIMQACWALEPTHRPT--------------FQQICSFLQE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQFG----------------KTLGAGA----------------FGKVVEATA--FGLGKED-------------------------------AVLKVAVKMLK--STAHADE---------------------------KEALMSELKIMSHL--G-----------------------QHENIVNLLGACTHGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVLVITEYCCY--------------GDLLNFLRR--K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRDLLHFSSQVAQGMAFLASK---------------------------------------------NCIHRDV-----AARNVLLTN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHVAKIGDFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---LPVKWMAPESIFD--------------------------------CVYT-VQSDVWSYGILLWE-FSL--G--------------LNPYPG--I-----------------------------------------------LVNSKFYKLVKDG--YQMAQPAFAP-----------------------------------------------------------------------------------------------------KNIYSIMQACWALEPTHRPT--------------FQQICSFLQE
Activation segment
DFGLARDIMNDSNY--IVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---LPVKWMAPE
Binding pocket
KTLGAGAFGKVVEVAVKMLALMSELKIMSHLGENIVNLLGALVITEYCCYGDLLNFLRRFLASKNCIHRDVAARNVLLIGDFGLA
Ligand info
Orthosteric ligand
UF4
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6WXJ, Chain A