6WQX Chain D
EKC/KEOPS complex subunit TP53RK (TP53RK)
Inactive — 0.2%DFG-inαC-inATPlike · ANP
Resolution
2.53 Å
R-value
0.214
Predicted activity confidence0.2%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLDEVRLRGR
UniProt reference sequence
LSGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLDEVRLRGRKRSMVG
Aligned reference sequence
LSGL----------------ELVKQGA----------------EARVFRGRF----------------------------------------QGRAAVIKHRF--PKGYRHPALEARLG--------------------RRRTVQEARALLRC--R-----------------------RAGISAPVVFFVDYAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCLYMEEIEGS--------------VTVRDYIQS--TMET-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKTPQGLSNLAKTIGQVLARMHDE---------------------------------------------DLIHGDL-----TTSNMLLKP--PLE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLNIVLIDFGLSFISA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEDKGVDLYVLEKAFL--------------------------------STHPNTETVFEAFLKSYSTSSKK----------------------------------------------------------------------------------------ARPVLKKLDEVRLRGRKRSMVG-------------------------------------------------------------------------------------------------------------------------------------
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LSGL----------------ELVKQGA----------------EARVFRGRF----------------------------------------QGRAAVIKHRF--PKGYRHPALEARLG--------------------RRRTVQEARALLRC--R-----------------------RAGISAPVVFFVDYAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCLYMEEIEGS--------------VTVRDYIQS--TMET-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKTPQGLSNLAKTIGQVLARMHDE---------------------------------------------DLIHGDL-----TTSNMLLKP--PLE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLNIVLIDFGLSFISA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEDKGVDLYVLEKAFL--------------------------------STHPNTETVFEAFLKSYSTSSKK----------------------------------------------------------------------------------------ARPVLKKLDEVRLRGR-------------------------------------------------------------------------------------------------------------------------------------------
Activation segment
DFGLSFISA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPEDKGVDLYVLE
Binding pocket
ELVKQGAEARVFRAVIKHRRTVQEARALLRCRAGISAPVVFCLYMEEIE_GSVTVRDYIRMHDEDLIHGDLTTSNMLLLIDFGLS
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6WQX, Chain D