6VG3 Chain A
Inactive tyrosine-protein kinase 7 (PTK7)
Inactive — 36.1%DFG-outαC-in
Resolution
1.95 Å
R-value
0.192
Predicted activity confidence36.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDS
UniProt reference sequence
LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGD
Aligned reference sequence
LQPI----------------TTLGKSE----------------FGEVFLAKA--QGLEEGV-------------------------------AETLVLVKSLQ--SKDEQQ----------------------------QLDFRRELEMFGKL--------------------------NHANVVRLLGLCREAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PHYMVLEYVDL--------------GDLKQFLRI--SKSKDEKLKSQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSTKQKVALCTQVALGMEHLSNN---------------------------------------------RFVHKDL-----AARNCLVSA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRQVKVSALGLSKDVYNSEYY--HF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQAWVPLRWMSPEAILE--------------------------------GDFS-TKSDVWAFGVLMWEVFTH--G--------------EMPHGG--------------------------------------------------QADDEVLADLQAG--KARLPQPEGCP----------------------------------------------------------------------------------------------------SKLYRLMQRCWALSPKDRPS--------------FSEIASALGD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQPI----------------TTLGKSE----------------FGEVFLAKA--QGLEEGV-------------------------------AETLVLVKSLQ--SKDEQQ----------------------------QLDFRRELEMFGKL--------------------------NHANVVRLLGLCREAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PHYMVLEYVDL--------------GDLKQFLRI--SKSKDEKLKSQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLSTKQKVALCTQVALGMEHLSNN---------------------------------------------RFVHKDL-----AARNCLVSA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRQVKVSALGLSKDVYNSEYY--HF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQAWVPLRWMSPEAILE--------------------------------GDFS-TKSDVWAFGVLMWEVFTH--G--------------EMPHGG--------------------------------------------------QADDEVLADLQAG--KARLPQPEGCP----------------------------------------------------------------------------------------------------SKLYRLMQRCWALSPKDRPS--------------FSEIASALGD
Activation segment
ALGLSKDVYNSEYY--HF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQAWVPLRWMSPE
Binding pocket
TTLGKSEFGEVFLVLVKSLDFRRELEMFGKLNANVVRLLGLYMVLEYVDLGDLKQFLRIHLSNNRFVHKDLAARNCLVVSALGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6VG3, Chain A