6UNR Chain A
Activin receptor type-1 (ACVR1)
Active — 99.7%DFG-inαC-inATPlike · ANP
Resolution
2.2 Å
R-value
0.246
Predicted activity confidence99.7%
Structure info
Alternate conformation—
Missing atoms26
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ITLLECVGKGRYGEVWRGSWENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIAATLT
UniProt reference sequence
ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTK
Aligned reference sequence
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------ECVGKGR----------------YGEVWRGSW------------------------------------------ENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--H-ST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIAATLT-
Activation segment
DLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPE
Binding pocket
ECVGKGRYGEVWRVAVKIFSWFRETELYNTVMENILGFIASWLITHYHEMGSLYDYLQLTQGKPAIAHRDLKSKNILVIADLGLA
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6UNR, Chain A