6UNP Chain A
Bone morphogenetic protein receptor type-2 (BMPR2)
Active — 72.8%DFG-inαC-inATPlike,Allosteric · ADP
Resolution
2.3 Å
R-value
0.19
Predicted activity confidence72.8%
Structure info
Alternate conformationB
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPEVGTIRYMAPEVLEGAVNLRDESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWGQDAEARLTAQAEERMAELMMIWE
UniProt reference sequence
LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAE
Aligned reference sequence
LKLL----------------ELIGRGR----------------YGAVYKGSL----------------------------------------DERPVAVKVFS--FAN-------------------------------RQNFINEKNIYRVP--LM----------------------EHDNIARFIVGDERVT--ADGRM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYLLVMEYYPN--------------GSLCKYLSL--H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSDWVSSCRLAHSVTRGLAYLHTE--LPRGDHYKP----------------------------------AISHRDL-----NSRNVLVKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGTCVISDFGLSMRLTGNRLV--RPGEEDNAA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISEVGTIRYMAPEVLEG--AVNLRDC-----------------------ESAL-KQVDMYALGLIYWEIFMR--CTDLFPGESVPEY--QMAFQT--EVGNH-------------------------------------------PTFEDMQVLVSRE--KQRPKFPEAWKENSLAV----------------------------------------------------------------------------------------------RSLKETIEDCWDQDAEARLT--------------AQCAEERMAE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKLL----------------ELIGRGR----------------YGAVYKGSL----------------------------------------DERPVAVKVFS--FAN-------------------------------RQNFINEKNIYRVP--LM----------------------EHDNIARFIVGDERVT--ADGRM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYLLVMEYYPN--------------GSL-KYLSL--H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSDWVSSCRLAHSVTRGLAYLHTE--LPRGDHYKP----------------------------------AISHRDL-----NSRNVLVKN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGTCVISDFGLSMRLTGNRLV--RP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVGTIRYMAPEVLEG--AVNLRD------------------------ESAL-KQVDMYALGLIYWEIFMR--CTDLFPGESVPEY--QMAFQT--EVGNH-------------------------------------------PTFEDMQVLVSRE--KQRPKFPEAWKENSLAV----------------------------------------------------------------------------------------------RSLKETIEDCWGQDAEARLT--------------AQ-AEERMAE
Activation segment
DFGLSMRLTGNRLV--RP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVGTIRYMAPE
Binding pocket
ELIGRGRYGAVYKVAVKVFNFINEKNIYRVPLDNIARFIVGLLVMEYYPNGSL_KYLSLDHYKPAISHRDLNSRNVLVISDFGLS
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
ADP
Ligand typeATPlike,Allosteric
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6UNP, Chain A