6UNA Chain A
Mitogen-activated protein kinase 12 (MAPK12)
Inactive — 0.2%DFG-inαC-in
Resolution
2.55 Å
R-value
0.198
Predicted activity confidence0.2%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GFYRQEVTKTAWEVRAVYRDLRPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSF
UniProt reference sequence
YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF
Aligned reference sequence
YRDL----------------QPVGSGA----------------YGAVCSAVD--GR------------------------------------TGAKVAIKKLY--RPFQSELF--------------------------AKRAYRELRLLKHM--------------------------RHENVIGLLDVFTPDE--TLDDFT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFYLVMPFMG---------------TDLGKLMKH--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLGEDRIQFLVYQMLKGLRYIHAA---------------------------------------------GIIHRDL-----KPGNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLARQADSEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVVTRWYRAPEVILN--W-----------------------------MRYT-QTVDIWSVGCIMAEMITG-----------------KTLFKG--------------------------------------------------SDHLDQLKEIMKV--TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS-----------------------------------------------------------------------PLAVNLLEKMLVLDAEQRVT--------------AGEALAHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YRDL----------------RPVGSGA----------------YGAVCSAVD--GR------------------------------------TGAKVAIKKLY--RPFQSELF--------------------------AKRAYRELRLLKHM--------------------------RHENVIGLLDVFTPDE--TLDDFT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFYLVMPFMG---------------TDLGKLMKH--E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLGEDRIQFLVYQMLKGLRYIHAA---------------------------------------------GIIHRDL-----KPGNLAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELKILDFGLA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTRWYRAPEVILN--W-----------------------------MRYT-QTVDIWSVGCIMAEMITG-----------------KTLFKG--------------------------------------------------SDHLDQLKEIMKV--TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS-----------------------------------------------------------------------PLAVNLLEKMLVLDAEQRVT--------------AGEALAHPYF
Activation segment
DFGLA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTRWYRAPE
Binding pocket
RPVGSGAYGAVCSVAIKKLRAYRELRLLKHMRENVIGLLDVYLVMPFMG_TDLGKLMKHYIHAAGIIHRDLKPGNLAVILDFGLA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6UNA, Chain A