6UL8 Chain A
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Inactive — 10.3%DFG-inαC-inType1.5_Back · Q9J
Resolution
2.68 Å
R-value
0.185
Predicted activity confidence10.3%
Structure info
Alternate conformationB
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AISSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHILLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLCKWGTIIYMPPENYESIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK
UniProt reference sequence
LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEP
Aligned reference sequence
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHLH--IHTPLLDSE-------------------------RKDVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADFGLSKWRMMSLSQ--SRSSKS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APEGGTIIYMPPENYEP--GQK---------------------------SRAS-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LADL----------------RYLSRGA----------------SGTVSSARH--AD------------------------------------WRVQVAVKHLH--I---LLDSE-------------------------RKDVLREAEILHKA--------------------------RFSYILPILGICNEPE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLGIVTEYMPN--------------GSLNELLHR--KTEYP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVAWPLRFRILHEIALGVNYLHNM--TP-----------------------------------------PLLHHDL-----KTQNILLDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFHVKIADFGLCKW-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTIIYMPPENYE------------------------------------S-IKHDIYSYAVITWEVLSR-----------------KQPFED--V-----------------------------------------------TNPLQIMYSVSQG--HRPVINEESLPYDIPHR----------------------------------------------------------------------------------------------ARMISLIESGWAQNPDERPS--------------FLKCLIELEP
Activation segment
DFGLCKW-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTIIYMPPE
Binding pocket
RYLSRGASGTVSSVAVKHLDVLREAEILHKARSYILPILGIGIVTEYMPNGSLNELLHRHNMTPPLLHHDLKTQNILLIADFGLC
Ligand info
Orthosteric ligand
Q9J
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6UL8, Chain A