6UIP Chain C
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Inactive — 23.5%DFG-inαC-inType1 · Q8J
Resolution
3.7 Å
R-value
0.272
Predicted activity confidence23.5%
Structure info
Alternate conformation—
Missing atoms0
Missing residues9
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KERKVYNDGYDDDNYDYIVKNGEKYEIDSLIGKGSFGQVVKAYDWVAIKIIKNKKAFLNQAQIEVRLLELMNKHIVHRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPIIHCDLKPENILLCNPKRSAIKIVDFGYQIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTREYKPPGTRKLHNILGVETGGPGGRRVADYLKFKDLILRMLDYDPKTRIQPYYALQHS
UniProt reference sequence
YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
Aligned reference sequence
YEID----------------SLIGKGS----------------FGQVVKAYD--RV------------------------------------EQEWVAIKIIK--NKKAF-----------------------------LNQAQIEVRLLELM--NKHDTE------------------MKYYIVHLKRHFMFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFEMLS---------------YNLYDLLRN--TNFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSLNLTRKFAQQMCTALLFLATP--EL-----------------------------------------SIIHCDL-----KPENILLCN--PK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSAIKIVDFGSSCQLGQRI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQYIQSRFYRSPEVLLG--------------------------------MPYD-LAIDMWSLGCILVEMHTG-----------------EPLFSG--------------------------------------------------ANEVDQMNKIVEV--LGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADY--------------------------------------LKFKDLILRMLDYDPKTRIQ--------------PYYALQHSFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEID----------------SLIGKGS----------------FGQVVKAYD-------------------------------------------WVAIKIIK--NKKAF-----------------------------LNQAQIEVRLLELM--NKH-------------------------IVH--RHFMFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLCLVFEMLS---------------YNLYDLLRN--TNFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSLNLTRKFAQQMCTALLFLATP----------------------------------------------IIHCDL-----KPENILLCN--PK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSAIKIVDFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ-IQSRFYRSPEVLLG--------------------------------MPYD-LAIDMWSLGCILVEMHTG-----------------EPLFSG--------------------------------------------------ANEVDQMNKIVEV--LGIPPAHILDQAPKARKFFEKLPDGTWNLKKT----REYKPPGTRKLHNILGVETGGPGGRR-------VADY--------------------------------------LKFKDLILRMLDYDPKTRIQ--------------PYYALQHS--
Activation segment
DFG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQ-IQSRFYRSPE
Binding pocket
SLIGKGSFGQVVKVAIKIIQAQIEVRLLELMN__IVH__RHCLVFEMLS_YNLYDLLRNATP___IIHCDLKPENILLIVDFG__
Ligand info
Orthosteric ligand
Q8J
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6UIP, Chain C