6U5L Chain A
Serine/threonine-protein kinase ULK4 (ULK4)
Inactive — 1.0%DFG-inαC-inType1 · 3RJ
Resolution
1.75 Å
R-value
0.192
Predicted activity confidence1.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
SGMENFILYEEIGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWVRLTREIKHKNIVTFHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEASMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKAFA
UniProt reference sequence
FILYEEIGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWVRLTREIKHKNIVTFHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEGGGDNGENVLKKSMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFW
Aligned reference sequence
FILY----------------EEIGRGS----------------KTVVYKGRR--KGT-----------------------------------INFVAILCTDK--CK--------------------------------RPEITNWVRLTREI--------------------------KHKNIVTFHEWYETSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLWLVVELCTG--------------GSLKTVIAQ--DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPEDVVREFGIDLISGLHHLHKL---------------------------------------------GILFCDI-----SPRKILLEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGTLKFSNFCLAKVEGENLEE--FFALVAAEEGGGDNGENVLKKSMK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVKGSPVYTAPEVVRG--------------------------------ADFS-ISSDLWSLGCLLYEMFSG-----------------KPPFFS--------------------------------------------------ESISELTEKILCE--DPLPPIPKDSSRPKAS-----------------------------------------------------------------------------------------------SDFINLLDGLLQRDPQKRLT--------------WTRLLQHSFW
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FILY----------------EEIGRGS----------------KTVVYKGRR--KGT-----------------------------------INFVAILCTDK--CK--------------------------------RPEITNWVRLTREI--------------------------KHKNIVTFHEWYETSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLWLVVELCTG--------------GSLKTVIAQ--DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPEDVVREFGIDLISGLHHLHKL---------------------------------------------GILFCDI-----SPRKILLEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGTLKFSNFCLAKVEGENLEE--FFALVAAEE-----------ASMK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVKGSPVYTAPEVVRG--------------------------------ADFS-ISSDLWSLGCLLYEMFSG-----------------KPPFFS--------------------------------------------------ESISELTEKILCE--DPLPPIPKDSSRPKAS-----------------------------------------------------------------------------------------------SDFINLLDGLLQRDPQKRLT--------------WTRLLQHSFW
Activation segment
NFCLAKVEGENLEE--FFALVAAEE-----------ASMK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVKGSPVYTAPE
Binding pocket
EEIGRGSKTVVYKVAILCTEITNWVRLTREIKKNIVTFHEWWLVVELCTGGSLKTVIAQHLHKLGILFCDISPRKILLFSNFCLA
Ligand info
Orthosteric ligand
3RJ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6U5L, Chain A