6U0K Chain A
Tau-tubulin kinase 2 (TTBK2)
Active — 100.0%DFG-inαC-inType1 · DTQ
Resolution
1.74 Å
R-value
0.193
Predicted activity confidence100.0%
Structure info
Alternate conformationA
Missing atoms4
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LDILSVGILVKERWKVLRKIGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWE
UniProt reference sequence
WKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDN
Aligned reference sequence
WKVL----------------RKIGGGG----------------FGEIYDALD--ML------------------------------------TRENVALKVES--AQQP------------------------------KQVLKMEVAVLKKL--Q-----------------------GKDHVCRFIGCGRNDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNYVVMQLQG---------------RNLADLRRS--QSRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTISTTLRLGRQILESIESIHSV---------------------------------------------GFLHRDI-----KPSNFAMGR--FPST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CRKCYMLDFGLARQFTNSCGD--VRPPRAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASINAHRN--------------------------------REMG-RHDDLWSLFYMLVEFVVG-----------------QLPWRK--I-----------------------------------------------KDKEQVGSIKERY--DHRLMLKHLP-----------------------------------------------------------------------------------------------------PEFSIFLDHISSLDYFTKPD--------------YQLLTSVFDN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
WKVL----------------RKI-GGG----------------FGEIYDALD--ML------------------------------------TRENVALKVES--AQQP------------------------------KQVLKMEVAVLKKL--Q-----------------------GKDHVCRFIGCGRNDR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FNYVVMQLQG---------------RNLADLRRS--QSRG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TFTISTTLRLGRQILESIESIHSV---------------------------------------------GFLHRDI-----KPSNFAMGR--FPST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CRKCYMLDFGLARQFTNSCGD--VRPPRAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASINAHRN--------------------------------REMG-RHDDLWSLFYMLVEFVVG-----------------QLPWRK--I-----------------------------------------------KDKEQVGSIKERY--DHRLMLKHLP-----------------------------------------------------------------------------------------------------PEFSIFLDHISSLDYFTKPD--------------YQLLTSVFDN
Activation segment
DFGLARQFTNSCGD--VRPPRAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGFRGTVRYASIN
Binding pocket
RKIGG_GFGEIYDVALKVEVLKMEVAVLKKLQDHVCRFIGCYVVMQLQG_RNLADLRRSSIHSVGFLHRDIKPSNFAMMLDFGLA
Ligand info
Orthosteric ligand
DTQ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6U0K, Chain A