6TUA Chain A
Tyrosine-protein kinase RYK (RYK)
Inactive — 0.0%DFG-inαC-in
Resolution
2.38 Å
R-value
0.197
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms7
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
YPTLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
UniProt reference sequence
ITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTE
Aligned reference sequence
ITLK----------------DVLQEGT----------------FGRIFHGIL--IDEKDPN-------------------------------KEKQAFVKTVK--DQASEIQ---------------------------VTMMLTESCKLRGL--------------------------HHRNLLPITHVCIEEG--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPYMNW--------------GNLKLFLRQ--CKLVEANNPQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AISQQDLVHMAIQIACGMSYLARR---------------------------------------------EVIHKDL-----AARNCVIDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLQVKITDNALSRDLFPMDYH--CLG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNENRPVRWMALESLVN--------------------------------NEFS-SASDVWAFGVTLWELMTL--G--------------QTPYVD--------------------------------------------------IDPFEMAAYLKDG--YRIAQPINCP-----------------------------------------------------------------------------------------------------DELFAVMACCWALDPEERPK--------------FQQLVQCLTE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLK----------------DVLQEGT----------------FGRIFHGIL--ID-------------------------------------EKQAFVKTVK--DQASEIQ---------------------------VTMMLTESCKLRGL--------------------------HHRNLLPITHVCIEEG--E-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPMVILPYMNW--------------GNLKLFLRQ--CKLVEANNPQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AISQQDLVHMAIQIACGMSYLARR---------------------------------------------EVIHKDL-----AARNCVIDD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLQVKITDNALSRDLFPMDYH--CL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENRPVRWMALESLVN--------------------------------NEFS-SASDVWAFGVTLWELMTL--G--------------QTPYVD--------------------------------------------------IDPFEMAAYLKDG--YRIAQPINCP-----------------------------------------------------------------------------------------------------DELFAVMACCWALDPEERPK--------------FQQLVQCLTE
Activation segment
DNALSRDLFPMDYH--CL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENRPVRWMALE
Binding pocket
DVLQEGTFGRIFHAFVKTVMMLTESCKLRGLHRNLLPITHVMVILPYMNWGNLKLFLRQYLARREVIHKDLAARNCVIITDNALS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6TUA, Chain A