6TU9 Chain A
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
Inactive — 0.9%DFG-outαC-inType1 · 0LI
Resolution
1.94 Å
R-value
0.21
Predicted activity confidence0.9%
Structure info
Alternate conformation—
Missing atoms31
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWMEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSW
UniProt reference sequence
VRFMEELGECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS
Aligned reference sequence
VRFM----------------EELGECA----------------FGKIYKGHL--YLPGMD--------------------------------HAQLVAIKTLK--DYNNPQQ---------------------------WTEFQQEASLMAEL--------------------------HHPNIVCLLGAVTQEQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCMLFEYINQ--------------GDLHEFLIM--RSPHSDVGCSSDEDGTVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDHGDFLHIAIQIAAGMEYLSSH---------------------------------------------FFVHKDL-----AARNILIGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLHVKISDLGLSREIYSADYY--RVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKSLLPIRWMPPEAIMY--------------------------------GKFS-SDSDIWSFGVVLWEIFSF--G--------------LQPYYG--------------------------------------------------FSNQEVIEMVRKR--QLLPCSEDCP-----------------------------------------------------------------------------------------------------PRMYSLMTECWNEIPSRRPR--------------FKDIHVRLRS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VRFM----------------EELGECA----------------FGKIYKGHL--YLPGMD--------------------------------HAQLVAIKTLK--DYNNPQQ---------------------------WMEFQQEASLMAEL--------------------------HHPNIVCLLGAVTQEQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVCMLFEYINQ--------------GDLHEFLIM--R--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLDHGDFLHIAIQIAAGMEYLSSH---------------------------------------------FFVHKDL-----AARNILIGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLHVKISDLGLSREIYSADYY--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLLPIRWMPPEAIMY--------------------------------GKFS-SDSDIWSFGVVLWEIFSF--G--------------LQPYYG--------------------------------------------------FSNQEVIEMVRKR--QLLPCSEDCP-----------------------------------------------------------------------------------------------------PRMYSLMTECWNEIPSRRPR--------------FKDIHVRLRS
Activation segment
DLGLSREIYSADYY--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLLPIRWMPPE
Binding pocket
EELGECAFGKIYKVAIKTLEFQQEASLMAELHPNIVCLLGACMLFEYINQGDLHEFLIMYLSSHFFVHKDLAARNILIISDLGLS
Ligand info
Orthosteric ligand
0LI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6TU9, Chain A