6TSZ Chain U
Serine/threonine-protein kinase ULK4 (ULK4)
Inactive — 3.6%DFG-inαC-inATPlike · AGS
Resolution
1.9 Å
R-value
0.203
Predicted activity confidence3.6%
Structure info
Alternate conformation—
Missing atoms10
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
NLYFQENFILYEEIGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWVRLTREIKHKNIVTFHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEGGDNGENVLKKSMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKAFA
UniProt reference sequence
FILYEEIGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWVRLTREIKHKNIVTFHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEGGGDNGENVLKKSMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFW
Aligned reference sequence
FILY----------------EEIGRGS----------------KTVVYKGRR--KGT-----------------------------------INFVAILCTDK--CK--------------------------------RPEITNWVRLTREI--------------------------KHKNIVTFHEWYETSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLWLVVELCTG--------------GSLKTVIAQ--DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPEDVVREFGIDLISGLHHLHKL---------------------------------------------GILFCDI-----SPRKILLEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGTLKFSNFCLAKVEGENLEE--FFALVAAEEGGGDNGENVLKKSMK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVKGSPVYTAPEVVRG--------------------------------ADFS-ISSDLWSLGCLLYEMFSG-----------------KPPFFS--------------------------------------------------ESISELTEKILCE--DPLPPIPKDSSRPKAS-----------------------------------------------------------------------------------------------SDFINLLDGLLQRDPQKRLT--------------WTRLLQHSFW
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FILY----------------EEIGRGS----------------KTVVYKGRR--KGT-----------------------------------INFVAILCTDK--CK--------------------------------RPEITNWVRLTREI--------------------------KHKNIVTFHEWYETSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLWLVVELCTG--------------GSLKTVIAQ--DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPEDVVREFGIDLISGLHHLHKL---------------------------------------------GILFCDI-----SPRKILLEG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGTLKFSNFCLAKVEGENLEE--FFALVAAEE-GGDNGENVLKKSMK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVKGSPVYTAPEVVRG--------------------------------ADFS-ISSDLWSLGCLLYEMFSG-----------------KPPFFS--------------------------------------------------ESISELTEKILCE--DPLPPIPKDSSRPKAS-----------------------------------------------------------------------------------------------SDFINLLDGLLQRDPQKRLT--------------WTRLLQHSFW
Activation segment
NFCLAKVEGENLEE--FFALVAAEE-GGDNGENVLKKSMK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRVKGSPVYTAPE
Binding pocket
EEIGRGSKTVVYKVAILCTEITNWVRLTREIKKNIVTFHEWWLVVELCTGGSLKTVIAQHLHKLGILFCDISPRKILLFSNFCLA
Ligand info
Orthosteric ligand
AGS
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6TSZ, Chain U