6TND Chain A
Dual specificity protein kinase TTK (TTK)
Inactive — 0.0%DFG-inαC-inType1.5_Back · 8RH
Resolution
2.58 Å
R-value
0.19
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPTVNYMPPEAIKDMISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQI
UniProt reference sequence
YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV
Aligned reference sequence
YSIL----------------KQIGSGG----------------SSKVFQVLN--E-------------------------------------KKQIYAIKYVN--LEEADNQT--------------------------LDSYRNEIAYLNKL--QQ----------------------HSDKIIRLYDYEITDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIYMVMECGN---------------IDLNSWLKK--KK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIDPWERKSYWKNMLEAVHTIHQH---------------------------------------------GIVHSDL-----KPANFLIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGMLKLIDFGIANQMQPDTTS--VVK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSQVGTVNYMPPEAIKD--MSSSRENGKSK-------------------SKIS-PKSDVWSLGCILYYMTYG-----------------KTPFQQ--I-----------------------------------------------INQISKLHAIIDP--NHEIEFPDIPE----------------------------------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS--------------IPELLAHPYV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YSIL----------------KQIGSGG----------------SSKVFQVLN--E-------------------------------------KKQIYAIKYVN--LEEADNQT--------------------------LDSYRNEIAYLNKL--QQ----------------------HSDKIIRLYDYEITDQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIYMVMECGN---------------IDLNSWLKK--KK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIDPWERKSYWKNMLEAVHTIHQH---------------------------------------------GIVHSDL-----KPANFLIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGMLKLIDFGIANQMQP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVNYMPPEAIKD--M-------------------------------IS-PKSDVWSLGCILYYMTYG-----------------KTPFQQ--I-----------------------------------------------INQISKLHAIIDP--NHEIEFPDIPE----------------------------------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS--------------IPELLAHPYV
Activation segment
DFGIANQMQP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVNYMPPE
Binding pocket
KQIGSGGSSKVFQYAIKYVSYRNEIAYLNKLQDKIIRLYDYYMVMECGN_IDLNSWLKKTIHQHGIVHSDLKPANFLILIDFGIA
Ligand info
Orthosteric ligand
8RH
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6TND, Chain A