6T29 Chain A
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
Inactive — 31.6%DFG-inαC-outType1 · M8Z
Resolution
1.484 Å
R-value
0.137
Predicted activity confidence31.6%
Structure info
Alternate conformationA
Missing atoms7
Missing residues1
Salt bridge (KinCore)—
Sequence info
PDB sequence
—
UniProt reference sequence
FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI
Aligned reference sequence
FEFK----------------ETLGTGA----------------FSEVVLAEE--KA------------------------------------TGKLFAVKCIP--KKALKGK---------------------------ESSIENEIAVLRKI--------------------------KHENIVALEDIYESPN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLYLVMQLVSG--------------GELFDRIVE--KG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYTEKDASTLIRQVLDAVYYLHRM---------------------------------------------GIVHRDL-----KPENLLYYS--QDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESKIMISDFGLSKMEGKGDVM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STACGTPGYVAPEVLAQ--------------------------------KPYS-KAVDCWSIGVIAYILLCG-----------------YPPFYD--------------------------------------------------ENDSKLFEQILKA--EYEFDSPYWDDIS--------------------------------------------------------------------------------------------------DSAKDFIRNLMEKDPNKRYT--------------CEQAARHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
—
Activation segment
—
Binding pocket
ETLGTGAFSEVVLFAVKCISIENEIAVLRKIKENIVALEDIYLVMQLVSGGELFDRIVEYLHRMGIVHRDLKPENLLYISDFGL_
Ligand info
Orthosteric ligand
M8Z
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 6T29, Chain A